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Clinical evaluation of novel bone graft substitutes for large bone defects
In certain serious cases, the bone loss is so extensive that the patient may end up in a dramatic condition: sick leave prolonged over several years, repeated heavy surgeries, and major psychosocial problems that can lead to the amputation of the affected limb and the social breakdown of the individual. The standard surgical procedures for bone repair rely on the use of bone autograft, harvested from patient’s iliac crests. This approach, however, has several disadvantages: (i) the quantity of bone available on the iliac crests is low, limiting the potential for bone repair, and (ii) the harvesting procedure is an additional surgical intervention that can lead to complications, especially severe pain.

In collaboration with the Lariboissière hospital, we clinically evaluate alternative bone graft substitutes for bone repair, sometimes for bone defects as big as 15cm long. The explored options rely on the association of osteo-conductive materials (favoring bone ingrowth) and cellularized products that will stimulate bone growth.
Bone graft substitute. The exoskeleton of Porites (coral) presents interesting properties as bone graft substitute such as a high porosity or a calcium carbonate composition.
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