LAB OVERVIEW
RESEARCH AREAS
EDUCATION
PUBLICATIONS
Stimulating  MSC with bone morphogenetic proteins
Another strategy to improve bone repair consists in recruiting local osteocompetent cells (in periphery of the bone defect) via the use of bioactive factors. In that perspective, BMPs (Bone Morphogenetic Protein) are of particular interest as they are osteinductive molecules (i.e. inducing bioactive cascades leading to new bone formation) with a specific action on bone and cartilage.
In clinical practice, BMP-2 is actually use for different medical applications where new bone formation is required. It is then added in absorbable collagen sponges which will deliver the BMP2 as they get degraded. Supra-physiological doses (in the tens of milligrams range) are, however, required for such applications because of the low affinity of BMP-2 for collagen, risking unwanted side effects and raising the cost of such therapeutic to levels prohibitive for a large scale clinical use.
Measure of the active BMP
Click to enlarge
Refrrence
The B2OA, therefore, aims to test new systems of controlled release of BMP in order to minimize the risk and the cost associated with this therapeutical strategy.
INTRANET
OUR PLATFORM
USEFUL LINKS
TUTORAL AUTHORITIES
OUR PARTNERS