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Evaluating the effects of scaffold macro-architecture on MSC
Scaffold architecture is known to influence biocompatibility and osteoconductivity (ability to support bone growth) of bone substitutes. For example, parameters such as pore size, porosity rate, level of pore interconnectivity, or microporosity significantly affect bone cell proliferation and differentiation in vitro and bone ingrowth in vivo.
Scaffold with different pore size
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One research project of the B2OA aims to optimize the scaffold architecture to maximize bone ingrowth with or without the help of MSC seeded prior to implantation.
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