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Optimizing MSC culture with mechanical stimulation
The repair of large bone defects require a large number of MSC: 10 million cells are needed, for example, for a defect of 3 cm long. One of the main challenges of MSC-based therapies is, therefore, to obtain such large number of functional MSC starting with a small biopsy of bone marrow.
In that perspective, 3D bioreactors, in which MSCs are seeded onto a porous scaffold itself perfused with culture medium, allow a better controlled and reproducible manner to amplify MSC compared to the classic 2D flask expansion.
The B2OA developed a column bioreactor for the culture of MSC seeded on coral scaffold and for volume pertinent to human large bone defect. Combining numerical tool (modeling) and in vitro experiments, the laboratory is optimizing the proliferation and differentiation of MSC within this bioreactor.
Bioreactor developed for the culture of MSC seeded on a scaffold
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